MANIC-DEPRESSIVE INSANITY AND VISCERAL DISEASE.

The Depressive Phase of Manic-Depressive Insanity

IT iS to the genius of Kraepelin, whose death in 1926 must have spared him the pain of encountering Nazism, that we owe both the title and our present conception of manic-depressive insanity. This conception embraces far more than the clinical close relationship which sometimes exists between states of mania and states of melancholia. A good deal, in fact, was known about this relationship befo...

Plasma Concentrations of y-Aminobutyric Test for Manic Depressive Disease?

y-Aminobutyric acid (GABA), an inhibitory neurotransminer that serves about one-third of brain neurons, is involved in the development of depression and in the treatment of depression and mania with pharmacological therapy. Brain activity of GABA may be conveniently measured in plasma, and changes in plasma concentrations of GABA reflect brain GABA activity. Plasma concentrations of GABA are si...

Genetics of manic depressive illness.

Manic depressive illness is a common and frequently debilitating familial psychiatric disorder. Efforts to understand the mechanisms of inheritance have been hindered by the complexity of the phenotype, which may range from benign mood swings to chronic psychosis, and by apparently nonmendelian modes of transmission. Early reports of linkage to chromosomal loci have fallen into doubt; however t...

[Affective equivalents in depressive and manic-depressive patients].

[Attempted suicide during depressive (unipolar) and manic depressive (bipolar) psychoses].